Blood in the urine

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Haematuria is the presence of red blood cells in the urine.

 Haematuria may indicate serious underlying problems such as cancer.

There is no clear relationship between the amount of bleeding and the severity of the underlying cause.

  Blood in the urine can come from anywhere in the urinary tract.

  Not all red urine is caused by blood.

All cases of haematuria should be fully investigated.

What is haematuria?

Haematuria is the presence of red blood cells in the urine. It can range from obvious bleeding to the microscopic detection of a few red blood cells in a routine urine sample.

When the urine is visibly coloured red by the amount of blood present it is called macroscopic haematuria. Blood that is not visible to the naked eye, but that is apparent on microscopic examination or with a urine test strip is called microscopic haematuria.

Unfortunately there is a poor correlation between the degree of haematuria and the severity of any underlying cause. An older person with visible haematuria is more likely to have serious underlying pathology than a younger person with microscopic haematuria and no symptoms. All people with haematuria need further investigation.

What are the causes of haematuria?

Blood in the urine can come from anywhere in the urinary tract: from the kidneys at the top down to the urethra (tube that carries urine from the bladder to the exterior).

There is a very long list of possible causes, but infections, stones, tumours or trauma (injury) account for the majority of cases.

In a person over 40 years of age with painless macroscopic haematuria, the most important cause to exclude is bladder cancer. Three main types of cancer occur in the bladder. The lining of the bladder, the ureter and the drainage system of the kidney consist of transitional cells. The most commonly found cancer is called transitional cell carcinoma. Cancers are usually named after the cells from which they originate.

The two other types of cancer found in the bladder are called squamous carcinoma and adenocarcinoma. Squamous carcinoma classically occurs after many years of bladder irritation as is seen with chronic bilharzia.

Adenocarcinoma of the bladder is rare. Its name is derived from the fact that the cancer contains gland-like elements.

Possible causes of bleeding from the upper urinary tract

Kidney

       Trauma

Blunt

Penetrating

 Kidney stones

Tumours

       Carcinoma of renal parenchyma (“meat” of the kidney)

       Transitional cell carcinoma of the renal pelvis (cancer of the lining of drainage system of the kidney, see above)

       Angiomyolipoma (a benign tumour of the kidney containing large numbers of blood vessels and fat, prone to spontaneous bleeding)

       Infections

       Tuberculosis

       Pyogenic infections – which are infections caused by pus forming bacteria

       Congenital (born with) disorders

       Polycystic kidney disease

       Renal cysts

       Bleeding disorders

       Haemophilia

       Leukemia

       Sickle cell disease

       Anticoagulant therapy such as warfarin

       Vascular causes

       Renal emboli (blood clots)

       Renal vein thrombosis

       Interstitial renal disease

       Glomerulonephritis

       IgA Nephropathy

Ureter (drainage tube of the kidney)

       Trauma (rare in isolation)

       Infection

       Ureteric stones

       Ureteric tumours (rare)

       Transitional cell carcinoma (cancer of the lining of the ureter, see above)

Possible causes of bleeding from the lower urinary tract

Bladder

       Trauma

       Infections

       Haemorrhagic cystitis (severe cystitis associated with bleeding from the bladder)

       Tuberculosis

       Schistosomiasis (Bilharzia)

       Stones

       Tumours

       Transitional cell carcinoma (see above)

       Squamous cell carcinoma (see above)

       Adenocarcinoma (see above)

       Radiation

       Exercise induced haematuria (long distance running can cause the layers of the empty bladder to rub on each other, thereby causing bleeding)

       Drugs

       Cyclophosphamide – a drug used in the treatment of cancer

Prostate

       Benign prostatic hyperplasia (BPH)

       Prostate cancer

       Prostatitis – infection of the prostate gland

Urethra

       Trauma

       Urethral tumours (very rare)

       Urethritis – infection of the urethra

When is red urine not haematuria?

The most common cause of a false positive finding of haematuria is contamination of the urine sample with menstrual blood.

Certain food dyes and beetroot can also render the urine red.

Several drugs such as pyridium (for pain relief of the urinary tract) and the anti-tuberculosis drug rifampacin change the colour of the urine to orange and can be confused with haematuria.

Haemoglobin, a breakdown product of red blood cells, will test positive on a urine test strip but will not be seen as red blood cells under the microscope. This means that the presence of heamoglobin in the urine will give a false positive test for blood.

How is haematuria diagnosed?

       Urine test strip (dipstix)

       Urine microscopy

Macroscopic haematuria may be very obvious with clearly visible blood or clots in the urine.

Microscopic haematuria can be detected using urine test strips (dipstix) or urine microscopy. Urine test strips are very sensitive to the presence blood in the urine, but the findings should be confirmed with microscopic examination.

The test strips react with haemoglobin from within the red blood cells. Haemoglobin within the urine can lead to false positive tests. False negative test strip analysis is very rare.

How is the cause of haematuria identified?

       History

       Physical examination

       Urine analysis

       Microscopy and culture

       Cytology – looking at cells under the microscope

       Imaging

       Intravenous pyelogram

       Ultrasound

       CT scanning

       Cystoscopy

A good clinical history and a thorough physical examination will often, but not always, indicate the likely source of bleeding.

A history of significant trauma is usually quite apparent. Blood that is seen only at the beginning of the stream is called initial haematuria and is characteristic of a urethral source. The passage of clear urine with blood and pain right at the end of the stream is called terminal haematuria, and is a classic sign of Bilharzia or a bladder stone. The stone causes pain and bleeding as the bladder empties around it. When all of the urine is discoloured by blood it is called total haematuria. In total haematuria the source can be anywhere in the urinary tract.

Loin or flank (side) pain associated with haematuria may indicate kidney pathology such as a stone, infection or a tumour. Bladder infections (cystitis) can bleed heavily. Patients with bleeding due to cystitis usually have the associated symptoms of bladder pain and burning with passing urine. Painless macroscopic haematuria in a middle-aged patient is most likely due to bladder cancer. In males the symptoms of bladder outflow obstruction such as a poor stream, hesitancy and straining with passing urine may indicate prostatic problems.

The physical examination of a patient with haematuria should be thorough and should include a rectal examination in a male and a vaginal examination in a female. The physical examination may detect a palpable mass in the kidney or an enlarged prostate gland.

The presence of blood in the urine should be confirmed on microscopy. The urine sample is cultured to rule out or prove infection as a cause. Urine cytology is a test that looks at the characteristics of cells found within the urine. It is useful in the follow-up of cases of known previous bladder cancer, where its main role is in the detection of tumour recurrence. Urine cytology is not usually used in the initial investigation of patients with haematuria.

Imaging of the upper urinary tract must always be performed in anybody with any degree of haematuria. Traditionally this was always done by means of an intravenous pyelogram (IVP). An IVP involves injecting an iodine-based contrast material into a vein. The contrast is excreted by the kidneys and is visible on X-ray. A series of films are taken after injection of contrast to show up the kidneys, ureters and bladder. IVP is still the most widely used initial investigation to detect upper tract causes for haematuria such as kidney stones or renal tumours.

An ultrasound scan combined with an ordinary abdominal X-ray is a viable alternative to IVP. The advantages of ultrasound are that it does not involve any radiation or contrast medium and that it is non-invasive. Ultrasound is also more sensitive than IVP in the detection of small tumours of the renal parenchyma. Ultrasound is less sensitive than IVP in the detection of small tumours of the drainage system of the kidney, however, and the accuracy of ultrasound is dependent on the skill of the person performing the procedure.

Ultrasound and IVP should be seen as complementary rather than mutually exclusive. In some patients it may be necessary to perform both tests in order to make an accurate diagnosis. If ultrasound or IVP suggests a mass in the kidney, then a CT scan is usually performed to define the mass in more detail. CT scanning is not usually used as a first-line investigation in haematuria.

An ultrasound scan or intravenous pyelogram (IVP) cannot rule out the presence of a bladder tumour. All patients with haematuria should undergo cystoscopy. Cystoscopy is the inspection of the inside of the urethra and bladder with a special instrument (cystoscope). The cystoscope is passed through the urethra into the bladder. The procedure can usually be performed under local anaesthetic as a day case.

If an abnormality such as a suspected bladder tumour is seen, a biopsy can be taken at the same time. A small biopsy can sometimes be taken under local anaesthetic but extensive biopsies are usually performed under spinal or general anaesthetic.

How is haematuria treated?

All cases of haematuria should be fully investigated in order to identify the underlying cause. There is no single treatment of haematuria, as different causes will be treated differently. Discussing the treatment options of all the possible causes of haematuria is beyond the scope of this article.

In cases of very heavy haematuria, the blood in the urine can form clots that can block the urethra and prevent bladder emptying. This leads to the painful condition of clot retention. In these instances it is often necessary to insert a large catheter and to irrigate the bladder with fluid to remove the clots. This is a temporary measure; the underlying cause will still need to be addressed as in any other case.

When to call the doctor

Blood in the urine should always be taken seriously. The amount of haematuria does not correlate with the severity of the underlying cause. Anyone with even one episode of blood in the urine should see a doctor.

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